MSc by Research in Cardiovascular - Exercise and The Failing Heart

University of Leeds

Heart failure is a complex syndrome with impairment of cardiac, respiratory, musculoskeletal and vascular function, all of which contribute to reduced quality of life and mortality. Exercise has established benefits in patients with heart failure but debate continues as to the most appropriate exercise modality. Our research investigates how the multiple organ and system impairments characteristic of heart failure integrate to cause fatigue and exercise intolerance, and limit quality of life and ultimately survival. We explore the mechanisms by which exercise exerts its benefits and the optimal training regimes that achieve these effects. Our approaches range from the measurement of gene expression to in vivo organ structure and function, complemented by in silico modelling.