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PhD/DPhil - Doctor of Philosophy
Leeds, Main
Full Time
Feb 2027
3 Year
We are interested in understanding the biology of human mesenchymal stem cells (MSCs) in vivo in health and disease, as a pre-requisite for the development of novel stem cell strategies. We research the in vivo phenotypes and topography of MSCS and how they can be used to treat osteoarthritis. We are exploring how to use minimally manipulated MSCs for immunomodulation applications including bone repair and cartilage tissue regeneration. Improved management and treatment of osteoarthritis centres around earlier diagnosis, improved non-surgical interventions, earlier and tissue sparing interventions including acellular scaffolds, and longer lasting joint replacements, with better targeting of interventions to meet stratified patient needs, greater precision and targeting in the design and delivery of devices, as well as improved reliability of these treatments.
